兔朊蛋白野生型和突变体NMR和X射线结构的分子动力学研究
Molecular dynamics studies on the NMR and X-ray structures of rabbit prion protein wild-type and mutants
摘要：
朊病毒疾病总是致命的和高度传染性的神经变性疾病，其影响多种哺乳动物物种，如绵羊、山羊、小鼠、人、黑猩猩、仓鼠、牛、麋鹿、鹿、貂、猫、鸡、猪、海龟、这些神经变性疾病是由可溶性正常细胞蛋白质转化为不溶性异常折叠感染性朊病毒引起的，并且该转化被认为涉及从主要的α-螺旋蛋白质到富含β-折叠结构的蛋白质的构象变化。这种构象变化可以通过分子动力学（MD）技术进行研究。对于兔子，经典研究表明它们对感染的敏感性低，但在2012年，据报道可以产生兔子朊病毒（尽管不是直接产生），并且兔子朊病毒具有感染性和可传播性（Proceedings of the National Academy of Sciences USA 109（13）：5080-5）。本文利用分子动力学技术研究了兔朊蛋白野生型和突变体的核磁共振和X射线分子结构，以了解兔朊蛋白和兔朊蛋白的特异性作用机制。
英文摘要：
Prion diseases are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species such as sheep, goats, mice, humans, chimpanzees, hamsters, cattle, elks, deer, minks, cats, chicken, pigs, turtles, etc. These neurodegenerative diseases are caused by the conversion from a soluble normal cellular protein into insoluble abnormally folded infectious prions and the conversion is believed to involve conformational change from a predominantly alpha-helical protein to one rich in beta-sheet structure. Such conformational changes may be amenable to study by molecular dynamics (MD) techniques. For rabbits, classical studies show they have a low susceptibility to be infected, but in 2012 it was reported that rabbit prion can be generated (though not directly) and the rabbit prion is infectious and transmissible (Proceedings of the National Academy of Sciences USA 109(13): 5080-5). This paper studies the NMR and X-ray molecular structures of rabbit prion protein wild-type and mutants by MD techniques, in order to understand the specific mechanism of rabbit prion protein and rabbit prions.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
