人Sirtuin家族的蛋白质相互作用网络
The protein-protein interaction network of human Sirtuin family
摘要：
蛋白质相互作用网络可用于研究人类疾病，并通过整体方法寻找可能的医疗保健。网络在理解生理过程中发挥着越来越重要的作用，如稳态，信号，空间和时间组织以及病理条件。在这篇文章中，我们展示了由人类Sirtuins（Sirt）决定的复杂的相互作用系统，主要涉及许多代谢过程以及不同的疾病。Sirtuin家族由七个同源Sirt-s组成，其具有结构相似的核心但不同的末端片段，长度相当可变和/或本质上无序。许多研究已经确定了它们的细胞定位以及生物学功能，尽管它们作用的分子机制实际上知之甚少。因此，这项工作的目的是定义，探索和理解Sirtuin相关的人类相互作用组。作为第一步，我们已经将实验确定的Sirtuin家族的蛋白质相互作用以及它们的第一和第二邻居整合到Sirtuin相关的子相互作用组中。我们的数据表明，Sirtuins的第二邻居网络包含整个人类相互作用组的25%，表现出无标度分布和顶级度节点之间的互连性。此外，Sirtuin子相互作用组显示出围绕核心的模块化结构，包括混合功能。最后，我们从Sirtuin亚相互作用组中提取了与癌症、衰老和翻译后修饰相关的Sirtuin家族网络的关键节点和拓扑空间的信息。
英文摘要：
Protein-protein interaction networks are useful for studying human diseases and to look for possible health care through a holistic approach. Networks are playing an increasing and important role in the understanding of physiological processes such as homeostasis, signaling, spatial and temporal organizations, and pathological conditions. In this article we show the complex system of interactions determined by human Sirtuins (Sirt) largely involved in many metabolic processes as well as in different diseases. The Sirtuin family consists of seven homologous Sirt-s having structurally similar cores but different terminal segments, being rather variable in length and/or intrinsically disordered. Many studies have determined their cellular location as well as biological functions although molecular mechanisms through which they act are actually little known. Therefore, the aim of this work was to define, explore and understand the Sirtuin-related human interactome. As a first step, we have integrated the experimentally determined protein-protein interactions of the Sirtuin-family as well as their first and second neighbors to a Sirtuin-related sub-interactome. Our data showed that the second-neighbor network of Sirtuins encompasses 25% of the entire human interactome, exhibits a scale-free degree distribution and interconnectedness among top degree nodes. Moreover, the Sirtuin sub interactome showed a modular structure around the core comprising mixed functions. Finally, we extracted from the Sirtuin sub-interactome subnets related to cancer, aging and post-translational modifications for information on key nodes and topological space of the subnets in Sirt family network.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
