果蝇胚胎中配对规则蛋白模式的建模与校准：从Even-skipped和Fushi-tarazu到Wingless表达网络
Modelling and calibration of pair-rule protein patterns in Drosophila embryo: From Even-skipped and Fushi-tarazu to Wingless expression networks
AI总结：
该研究对果蝇早期发育中Eve、Ftz配对规则蛋白的七条带模式建模校准，确定相关增强子抑制组合与调控关系，模型可复现基因突变实验，还拓展推断了Wg的十四条带模式，阐明了果蝇基因表达网络的层级结构。
摘要：
我们对果蝇胚胎前后轴上、早期发育阶段形成的Even-skipped（Eve）与Fushi-tarazu（Ftz）配对规则蛋白的七条带模式分布进行了建模与校准。我们确定了5个Eve增强子的推定抑制组合，并探究了Eve与Ftz互补模式之间的关联。Eve和Ftz的调控因子是具有胚胎位置依赖激活率的条带特异性DNA增强子，且受间隙蛋白家族调控。我们实现了Eve条带模式的出色数据匹配，校准后的模型可复现间隙基因突变实验。此外，研究还提出了从Eve和Ftz增强子推断Wingless（Wg）十四条带模式的拓展工作，阐明了果蝇早期发育中基因表达网络的层级结构。
英文摘要：
We modelled and calibrated the distributions of the seven-stripe patterns of Even-skipped (\textit{Eve}) and Fushi-tarazu (\textit{Ftz}) pair-rule proteins along the anteroposterior axis of the \textit{Drosphila} embryo, established during early development. We have identified the putative repressive combinations for five \textit{Eve} enhancers, and we have explored the relationship between \textit{Eve} and \textit{Ftz} for complementary patterns. The regulators of \textit{Eve} and \textit{Ftz} are stripe-specific DNA enhancers with embryo position-dependent activation rates and are regulated by the gap family of proteins. We achieved remarkable data matching of the \textit{Eve} stripe pattern, and the calibrated model reproduces gap gene mutation experiments. Extended work inferring the Wingless (\textit{Wg}) fourteen stripe pattern from \textit{Eve} and \textit{Ftz} enhancers have been proposed, clarifying the hierarchical structure of \textit{Drosphila}'s genetic expression network during early development.
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