用高功率超声对polymer泡沫组织支架进行后处理：一种增加孔互连性、孔径和流体输送的途径
Post-processing of polymer foam tissue scaffolds with high power ultrasound: a route to increased pore interconnectivity, pore size and fluid transport
摘要：
我们将厚的聚合物泡沫组织支架暴露于高功率超声，并研究其对孔结构开放性和通过支架的流体运输的影响。我们的分析得到了超声处理过程中液体摄取测量值的支持，并通过X射线计算机断层成像、扫描电子显微镜和声学显微镜对支架微结构进行成像。超声波处理可以使平均孔径增加10%以上。更引人注目的是液体吸收的改善：对于通过标准浸泡技术仅吸收40%水的支架，我们可以在大约一小时的暴露时间内常规地实现支架的完全饱和。这些所需的修改发生没有支架完整性的损失和可忽略的质量损失，并优化时，超声处理耦合到预润湿阶段与乙醇。我们的研究结果表明，高功率超声是一种高度针对性和有效的手段，以促进厚泡沫组织支架中的孔隙互连和流体输送。
英文摘要：
We expose thick polymer foam tissue scaffolds to high power ultrasound and study its effect on the openness of the pore architecture and fluid transport through the scaffold. Our analysis is supported by measurements of fluid uptake during insonification and imaging of the scaffold microstructure via x-ray computed tomography, scanning electron microscopy and acoustic microscopy. The ultrasonic treatment is found to increase the mean pore size by over 10%. More striking is the improvement in fluid uptake: for scaffolds with only 40% water uptake via standard immersion techniques, we can routinely achieve full saturation of the scaffold over approximately one hour of exposure. These desirable modifications occur with no loss of scaffold integrity and negligible mass loss, and are optimized when the ultrasound treatment is coupled to a pre-wetting stage with ethanol. Our findings suggest that high power ultrasound is a highly targetted and efficient means to promote pore interconnectivity and fluid transport in thick foam tissue scaffolds.
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