Nlrp1中串联重复序列的模式分析
Pattern Analysis of Tandem Repeats in Nlrp1
摘要：
基因串联重复序列的模式分析是理解基因表达和疾病发病机制不可缺少的计算手段。本研究应用计算模体模型和数据库技术研究了Nlrp1基因串联重复序列的分布，Nlrp1基因是检测入侵病原体免疫机制中的关键基因。研究了Nlrp1基因中单、二、三和四核苷酸串联重复序列的频率。分析Nlrp1基因的突变以鉴定核苷酸的插入、缺失和取代。本研究结果为今后的计算药物设计和生物医学工程在解决与免疫系统相关的疾病方面的工作提供了基础。
英文摘要：
Pattern analysis of tandem repeats in gene is an indispensable computational approach to the understanding of the gene expression and pathogenesis of diseases. This research applied a computational motif model and database techniques to study the distribution of tandem repeats in Nlrp1 gene, which is a critical gene to detect the invading pathogens in the immunologic mechanisms. The frequency of tandem repeats in Nlrp1 gene was studied for mono-, di-, tri-, and tetranucleotides. Mutations of Nlrp1 gene were analyzed to identify the insertion,deletion, and substitution of nucleotides. The results of this research provide a basis for future work in computational drug design and biomedical engineering in tackling diseases associated with immune system.
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