胃周缘细胞GIF串联重复序列的计算机模拟分析
In Silico Analysis of Tandem Repeats in GIF of Gastric Parietal Cells
摘要：
串联重复序列普遍存在于生物体基因组中，其突变形式在致病中起着至关重要的作用。在这项研究中，串联重复序列的胃内分泌因子（GIF）的胃周缘细胞已调查使用计算机模拟的方法。研究了六种核苷酸串联重复基序，包括单、二、三、四、五和六核苷酸。分析了该基因中重复基序的分布。本研究的结果提供了一个深入的生物分子机制和发病机制所涉及的GIF的胃周缘细胞。基于对胃周缘细胞GIF中串联重复序列的发现，生物医学科学家可以据此开发治疗策略和疾病标志物。
英文摘要：
Tandem repeats are ubiquitous in the genome of organisms and their mutated forms play a vital role in pathogenesis. In this study, tandem repeats in Gastric Intrinsic Factor (GIF) of gastric parietal cells have been investigated using an in silico approach. Six types of the nucleotide tandem repeat motifs have been investigated, including mono-, di-, tri-, tetra-, penta- and hexanucleotide. The distribution of the repeat motifs in the gene was analyzed. The results of this study provide an insight into the biomolecular mechanisms and pathogenesis implicated by the GIF of gastric parietal cells. Based on the findings of the tandem repeats in GIF of gastric parietal cells, therapeutic strategies and disease markers may be developed accordingly by the biomedical scientists.
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