电压动力学对感觉毛细胞模型反应特性的影响
Effect of voltage dynamics on response properties in a model of sensory hair cell
摘要：
听觉和前庭器官中的感觉毛细胞依赖于主动机制来实现高灵敏度和频率选择性。最近的实验研究已经证明了低等脊椎动物毛细胞在两个不同水平上的自我维持振荡。首先，发束可以经历自发的机械振荡。第二，已观察到跨毛细胞基底外侧膜的体细胞电压振荡。我们开发了一个生物物理模型的牛蛙的囊状毛细胞组成的两个隔间，机械和电气，研究如何机械和电压振荡相互作用，产生连贯的自我维持的振荡，以及这种相互作用如何有助于整体的敏感性和选择性的毛细胞。该模型采用了非线性机械随机发束系统耦合双向霍奇金-赫胥黎型系统描述体细胞离子电流。我们隔离区域的相干自发振荡的参数空间的模型，然后研究如何耦合之间的车厢影响毛细胞对外部机械扰动的敏感性。我们发现，自发电振荡可以显着提高毛细胞的敏感性和选择性。
英文摘要：
Sensory hair cells in auditory and vestibular organs rely on active mechanisms to achieve high sensitivity and frequency selectivity. Recent experimental studies have documented self-sustained oscillations in hair cells of lower vertebrates on two distinct levels. First, the hair bundle can undergo spontaneous mechanical oscillations. Second, somatic electric voltage oscillations across the baso-lateral membrane of the hair cell have been observed. We develop a biophysical model of the bullfrog's saccular hair cell consisting of two compartments, mechanical and electrical, to study how the mechanical and the voltage oscillations interact to produce coherent self-sustained oscillations and how this interaction contributes to the overall sensitivity and selectivity of the hair cell. The model incorporates nonlinear mechanical stochastic hair bundle system coupled bi-directionally to a Hodgkin-Huxley type system describing somatic ionic currents. We isolate regions of coherent spontaneous oscillations in the parameter space of the model and then study how coupling between compartments affect sensitivity of the hair cell to external mechanical perturbations. We show that spontaneous electrical oscillations may enhance significantly the sensitivity and selectivity of the hair cell.
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