理解个体发生和衰老理论的新途径
A New Approach to Understanding Ontogenesis and The Theory of Aging
摘要：
本文提出了一个多细胞生物衰老的新理论。与单细胞生物体相反，多细胞生物体的细胞背负着两部分基因组：管家和特化（多细胞），负责个体发育和终末分化。基因组的两个部分竞争有限的适应性资源，从而干扰基因组的管家部分在有丝分裂后细胞中充分执行修复和适应性功能的能力。完成本体发生程序的必要性导致基因组的多细胞组分的活性增加。因此，细胞资源分配到专门的基因组不断增加与时间。这导致有丝分裂后细胞的修复和适应能力的缺陷。对未来研究的建议集中在鉴定负责调节特化基因组生长速率和抑制细胞分裂能力的基因组。更好地理解基因组两部分之间的关系不仅有助于我们操纵个体发育和衰老，而且还将提高我们对癌症发展和个体发育的理解。
英文摘要：
This paper proposes an original theory of aging of multicellular organisms. The cells of multicellular organisms, in contrast to unicellular organisms, are burdened with a two- part genome: housekeeping and specialized (multicellular), responsible for ontogenesis and terminal differentiation. The two parts of the genome compete for limited adaptive resources thereby interfering with the ability of the house-keeping part of the genome to adequately perform reparative and adaptive functions in post mitotic cells. The necessity to complete the ontgenesis program, leads to increased activity of the multicellular components of the genome. As a result, the allocation of cellular resources to specialized genome con-tinuously increases with time. This leads to a deficit of reparative and adaptive capacity in post mitotic cells. Suggestions for future research focus on identifying groups of genes responsible for regulation of growth rate of specialized genome and suppressing ability of the cell division. A better understanding of the relationship between the two parts of the genome will not only help us to manipulate ontogenesis and aging, but will also improve our understanding of cancer development and ontogenesis.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
