系统动力学模拟维持原始T细胞库的过程
System Dynamics Modelling of the Processes Involving the Maintenance of the Naive T Cell Repertoire
摘要：
免疫系统衰老的研究，即免疫衰老，是一个相对较新的研究课题。它涉及了解免疫降解的过程，表明功能丧失的迹象可能导致死亡。尽管不可能预防免疫衰老，但了解其原因有很大的好处，这可能有助于扭转一些损害，从而提高预期寿命。影响免疫衰老过程的主要因素之一是个体中初始T细胞的数量和表型多样性。这项工作提出了一个审查的免疫衰老，提出系统动力学建模的过程中涉及的幼稚T细胞库的维护，并提出了一些初步的结果。
英文摘要：
The study of immune system aging, i.e. immunosenescence, is a relatively new research topic. It deals with understanding the processes of immunodegradation that indicate signs of functionality loss possibly leading to death. Even though it is not possible to prevent immunosenescence, there is great benefit in comprehending its causes, which may help to reverse some of the damage done and thus improve life expectancy. One of the main factors influencing the process of immunosenescence is the number and phenotypical variety of naive T cells in an individual. This work presents a review of immunosenescence, proposes system dynamics modelling of the processes involving the maintenance of the naive T cell repertoire and presents some preliminary results.
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