频率和幅度解码在基因调控中的可靠性
Reliability of frequency- and amplitude-decoding in gene regulation
摘要：
在生物化学信号中，信息通常被编码在振荡信号中。然而，这种编码策略相对于恒定信号的幅度编码方案的优点仍然不清楚。在这里，我们研究了一个简单的模型基因启动子响应振荡和恒定的转录因子信号的动力学。我们发现，在生物相关的参数制度的振荡输入可以产生一个更恒定的蛋白质水平比一个恒定的输入。我们的研究结果表明，振荡信号可以用来最大限度地减少噪音在基因调控。
英文摘要：
In biochemical signaling, information is often encoded in oscillatory signals. However, the advantages of such a coding strategy over an amplitude encoding scheme of constant signals remain unclear. Here we study the dynamics of a simple model gene promoter in response to oscillating and constant transcription factor signals. We find that in biologically-relevant parameter regimes an oscillating input can produce a more constant protein level than a constant input. Our results suggest that oscillating signals may be used to minimize noise in gene regulation.
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