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arXiv 1111.7125stat.AP
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一种小样本亚组和潜在生物标志物的视觉识别方法

A method for visual identification of small sample subgroups and potential biomarkers

Charlotte Soneson, Magnus Fontes

摘要:

为了在生物医学数据中发现以前未知的亚组并生成可检验的假设,视觉引导的探索性分析可能非常重要。在本文中,我们提出了一种新的相异性测度,可以在多维尺度框架内使用,以获得一个联合的低维表示的样本和变量的多元数据集,从而提供了一种替代传统的biplots。与biplots相比,我们的方法获得的表示是特别有用的数据集的探索性分析,其中有一小群样本共享异常高或低的值的变量。

英文摘要:

In order to find previously unknown subgroups in biomedical data and generate testable hypotheses, visually guided exploratory analysis can be of tremendous importance. In this paper we propose a new dissimilarity measure that can be used within the Multidimensional Scaling framework to obtain a joint low-dimensional representation of both the samples and variables of a multivariate data set, thereby providing an alternative to conventional biplots. In comparison with biplots, the representations obtained by our approach are particularly useful for exploratory analysis of data sets where there are small groups of variables sharing unusually high or low values for a small group of samples.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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