多细胞肿瘤球体的应力钳实验
Stress Clamp Experiments on Multicellular Tumor Spheroids
摘要：
微环境对肿瘤生长的确切作用知之甚少。尽管肿瘤与周围组织不断竞争，但对这种相互作用的机制知之甚少。使用一种新的实验方法，我们定量研究了机械应力对球状体细胞聚集体长期生长的影响。我们观察到，10 kPa的应力足以通过抑制主要在球状体核心的细胞增殖来显著降低生长。我们将结果与一个简单的数值模型进行比较，该模型用于描述力学在癌症进展中的作用。
英文摘要：
The precise role of the microenvironment on tumor growth is poorly understood. Whereas the tumor is in constant competition with the surrounding tissue, little is known about the mechanics of this interaction. Using a novel experimental procedure, we study quantitatively the effect of an applied mechanical stress on the long-term growth of a spheroid cell aggregate. We observe that a stress of 10 kPa is sufficient to drastically reduce growth by inhibition of cell proliferation mainly in the core of the spheroid. We compare the results to a simple numerical model developed to describe the role of mechanics in cancer progression.
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