胞质球体中的粘毛细不稳定性
Viscocapillary Instability in Cellular Spheroids
摘要：
我们描述了一种粘毛细血管的不稳定性，可以扰乱培养中的细胞聚集体的球形对称性，也称为多细胞球体。在构成球状体的细胞从直接的外部微环境获得其必需代谢物的条件下，球状体内存在从细胞分裂到其死亡的核心的外缘的永久细胞流。球对称性的扰动在组织内引起粘性剪切应力，其可以使聚集体不稳定。所提出的不稳定性本质上是粘毛细管的，并且不依赖于外部异质性，例如预先存在的血管图案或细胞可以施加拉力的基底的存在。它出现足够大的细胞-细胞粘附强度，细胞更新率，和代谢产物的供应，如我们的模型参数所描述的。由于培养中的多细胞球体是小的无血管肿瘤的良好模型系统，模仿体内发现的代谢物浓度梯度，我们可以推测我们的描述适用于癌症进展中的微肿瘤不稳定性。
英文摘要：
We describe a viscocapillary instability that can perturb the spherical symmetry of cellular aggregates in culture, also called multicellular spheroids. In the condition where the cells constituting the spheroid get their necessary metabolites from the immediate, outer microenvironment, a permanent cell flow exists within the spheroid from its outer rim where cells divide toward its core where they die. A perturbation of the spherical symmetry induces viscous shear stresses within the tissue that can destabilise the aggregate. The proposed instability is viscocapillary in nature and does not rely on external heterogeneities, such as a pre-existing pattern of blood vessels or the presence of a substrate on which the cells can exert pulling forces. It arises for sufficiently large cell-cell adhesion strengths, cell-renewal rates, and metabolite supplies, as described by our model parameters. Since multicellular spheroids in culture are good model systems of small, avascular tumours, mimicking the metabolite concentration gradients found in vivo, we can speculate that our description applies to microtumour instabilities in cancer progression.
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