星形胶质细胞介导LTP在单个海马突触的数学模型
A Mathematical model for Astrocytes mediated LTP at Single Hippocampal Synapses
摘要：
许多当代研究表明，星形胶质细胞在调节短和长形式的突触可塑性中起重要作用。有很少的实验模型，阐明星形胶质细胞的作用，在长时程增强（LTP）。最近，Perea & Araque（2007）证明了星形胶质细胞在单个海马突触处诱导LTP中的作用。他们提出了诱导这种N-甲基-D-天冬氨酸（NMDA）受体非依赖性LTP的纯粹突触前基础。此外，未研究这种突触前诱导的机制。在这篇文章中，我们提出了一个星形胶质细胞调节LTP的数学模型，它成功地模拟了Perea & Araque（2007）的实验结果。我们的研究表明逆行信使（可能是一氧化氮（NO））在这种突触前调节的LTP中发挥了作用。
英文摘要：
Many contemporary studies have shown that astrocytes play a significant role in modulating both short and long form of synaptic plasticity. There are very few experimental models which elucidate the role of astrocyte over Long-term Potentiation (LTP). Recently, Perea & Araque (2007) demonstrated a role of astrocytes in induction of LTP at single hippocampal synapses. They suggested a purely pre-synaptic basis for induction of this N-methyl-D- Aspartate (NMDA) Receptor-independent LTP. Also, the mechanisms underlying this pre-synaptic induction were not investigated. Here, in this article, we propose a mathematical model for astrocyte modulated LTP which successfully emulates the experimental findings of Perea & Araque (2007). Our study suggests the role of retrograde messengers, possibly Nitric Oxide (NO), for this pre-synaptically modulated LTP.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
