可收缩纤维束的粘弹性响应
Viscoelastic response of contractile filament bundles
摘要：
贴壁组织细胞的肌动蛋白细胞骨架经常凝聚成由肌球蛋白马达收缩的丝束，即所谓的应力纤维，其在细胞与其环境的机械相互作用中起着至关重要的作用。应力纤维通常在端点处附着于其环境，但也可能沿着其整个长度附着。我们介绍了一个理论模型，这样的收缩丝束结合被动粘弹性与主动收缩性。两种不同类型的边界条件的模型方程求解解析。自由边界对应于激光手术后的应力纤维收缩动力学，结果与实验数据吻合良好。施加循环变化的边界力，使我们能够计算一个单一的应力纤维的复模量。
英文摘要：
The actin cytoskeleton of adherent tissue cells often condenses into filament bundles contracted by myosin motors, so-called stress fibers, which play a crucial role in the mechanical interaction of cells with their environment. Stress fibers are usually attached to their environment at the endpoints, but possibly also along their whole length. We introduce a theoretical model for such contractile filament bundles which combines passive viscoelasticity with active contractility. The model equations are solved analytically for two different types of boundary conditions. A free boundary corresponds to stress fiber contraction dynamics after laser surgery and results in good agreement with experimental data. Imposing cyclic varying boundary forces allows us to calculate the complex modulus of a single stress fiber.
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