On a mathematical relation between the Eigen model and the asexual Wright-Fisher model

The competition between simple and complex evolutionary trajectories in asexual populations

On rugged fitness landscapes where sign epistasis is common, adaptation can often involve either individually beneficial "uphill" mutations or more complex mutational trajectories involving fitness valleys or plateaus. The dynamics of the evolutionary process determine the probability that evolution will take any specific path among a variety of competing possible trajectories. Understanding this evolutionary choice is essential if we are to understand the outcomes and predictability of adaptation on rugged landscapes. We present a simple model to analyze the probability that evolution will es…

An explicit transition density expansion for a multi-allelic Wright-Fisher diffusion with general diploid selection

Characterizing time-evolution of allele frequencies in a population is a fundamental problem in population genetics. In the Wright-Fisher diffusion, such dynamics is captured by the transition density function, which satisfies well-known partial differential equations. For a multi-allelic model with general diploid selection, various theoretical results exist on representations of the transition density, but finding an explicit formula has remained a difficult problem. In this paper, a technique recently developed for a diallelic model is extended to find an explicit transition density for an …

Wright-Fisher扩散的精确模拟

Exact simulation of the Wright-Fisher diffusion

针对Wright-Fisher扩散转移函数无闭式公式的问题，本文利用特征函数展开和回顾性拒绝思想，实现中性、选择及相关桥过程、Fleming-Viot过程和Kingman溯祖祖先过程的精确模拟。

Two-level Fisher-Wright framework with selection and migration: An approach to studying evolution in group structured populations

A framework for the mathematical modeling of evolution in group structured populations is introduced. The population is divided into a fixed large number of groups of fixed size. From generation to generation, new groups are formed that descend from previous groups, through a two-level Fisher-Wright process, with selection between groups and within groups and with migration between groups at rate $m$. When $m=1$, the framework reduces to the often used trait-group framework, so that our setting can be seen as an extension of that approach. Our framework allows the analysis of previously introd…

Critical population and error threshold on the sharp peak landscape for the Wright-Fisher model

We pursue the task of developing a finite population counterpart to Eigen's model. We consider the classical Wright-Fisher model describing the evolution of a population of size $m$ of chromosomes of length $\ell$ over an alphabet of cardinality $κ$. The mutation probability per locus is $q$. The replication rate is $σ>1$ for the master sequence and $1$ for the other sequences. We study the equilibrium distribution of the process in the regime where $\ell\to+\infty$, $m\to+\infty$, $q\to0$, $\ell q\to a\in\,]0,+\infty[$, $\frac{m}{\ell}\toα\in [0,+\infty]$. We obtain an equation $αψ(a)=\lnκ$ i…

Diffusion processes and coalescent trees

We dedicate this paper to Sir John Kingman on his 70th Birthday. In modern mathematical population genetics the ancestral history of a population of genes back in time is described by John Kingman's coalescent tree. Classical and modern approaches model gene frequencies by diffusion processes. This paper, which is partly a review, discusses how coalescent processes are dual to diffusion processes in an analytic and probabilistic sense. Bochner (1954) and Gasper (1972) were interested in characterizations of processes with Beta stationary distributions and Jacobi polynomial eigenfunctions. We d…