用于肿瘤细胞和新生血管的有效时间靶向的定量模型
Quantitative model for efficient temporal targeting of tumor cells and neovasculature
摘要：
细胞毒疗法和抗血管生成剂的组合正在成为治疗恶性肿瘤的最有前途的策略。然而，这些治疗的时机和顺序似乎在实现协同结果方面发挥着至关重要的作用。使用的数学建模方法，是基于现有的实验数据，我们调查的空间和时间靶向的肿瘤细胞和新生血管与纳米级输送系统。我们的模型表明，纳米级递送系统的实验成功关键取决于肿瘤组织内化疗药物的捕获。数值结果还表明，通过调整时间靶向机制，可以实现纳米级递送系统效率的实质性进一步改善。
英文摘要：
The combination of cytotoxic therapies and anti-angiogenic agents is emerging as a most promising strategy in the treatment of malignant tumors. However, the timing and sequencing of these treatments seem to play essential roles in achieving a synergic outcome. Using a mathematical modeling approach that is grounded on available experimental data, we investigate the spatial and temporal targeting of tumor cells and neovasculature with a nanoscale delivery system. Our model suggests that the experimental success of the nanoscale delivery system depends crucially on the trapping of chemotherapeutic agents within the tumor tissue. The numerical results also indicate that substantial further improvements in the efficiency of the nanoscale delivery system can be achieved through an adjustment of the temporal targeting mechanism.
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