收缩环的分子模型
Molecular Model of the Contractile Ring
摘要：
我们提出了一个模型的肌动蛋白收缩环的粘附动物细胞。该模型表明，在收缩期间，环内的肌动蛋白浓度以及环施加的功率都增加。我们证明了肌动蛋白聚合和解聚在整个胞质分裂中的关键作用，以及粘性耗散在动力学中的主导地位。胞质分裂动力学中的两个阶段（“双相胞质分裂”）的物理起源来自肌动蛋白密度的限制。该模型与广泛的测量分裂动物细胞的中间区是一致的。
英文摘要：
We present a model for the actin contractile ring of adherent animal cells. The model suggests that the actin concentration within the ring and consequently the power that the ring exerts both increase during contraction. We demonstrate the crucial role of actin polymerization and depolymerization throughout cytokinesis, and the dominance of viscous dissipation in the dynamics. The physical origin of two phases in cytokinesis dynamics ("biphasic cytokinesis") follows from a limitation on the actin density. The model is consistent with a wide range of measurements of the midzone of dividing animal cells.
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