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arXiv 1005.4753math.STstat.TH
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稀疏性下一般分布效应量的渐近贝叶斯最优性

Asymptotic Bayes optimality under sparsity for generally distributed effect sizes under the alternative

Florian Frommlet, Arijit Chakrabarti, Magdalena Murawska, Malgorzata Bogdan

摘要:

最近的结果渐近贝叶斯最优稀疏(ABOS)下的多个测试程序的扩展到相当普遍分布的影响大小的替代品。一个渐近框架被认为是测试的数量m和样本量m去无穷大,而真正的替代品的分数p收敛到零。它表明,在温和的限制下的损失函数非平凡的渐近推断是可能的,只有当n增加到无穷大至少在log m的速度。在此基础上,给出了在标称FWER(Family Wise差错率)水平α下的Bonferroni校正和在FDR水平α下的Benjamini-Hochberg(BH)方法渐近最优的精确条件。当n与log m成正比时,alpha可以保持不变,而当n以更快的速度增加到无穷大时,alpha必须大致收敛到零,就像n^(-1/2)一样。在这些条件下,Bonferroni校正在极端稀疏的情况下是ABOS,而BH很好地适应未知的稀疏水平。在本文的第二部分,这些最优性结果结转到模型选择的背景下,与正交回归的多元回归。贝叶斯信息准则的几个修改被认为是,控制FWER或FDR,并提供条件下,这些选择标准是ABOS。最后,在简短的模拟研究中检查了这些标准的性能。

英文摘要:

Recent results concerning asymptotic Bayes-optimality under sparsity (ABOS) of multiple testing procedures are extended to fairly generally distributed effect sizes under the alternative. An asymptotic framework is considered where both the number of tests m and the sample size m go to infinity, while the fraction p of true alternatives converges to zero. It is shown that under mild restrictions on the loss function nontrivial asymptotic inference is possible only if n increases to infinity at least at the rate of log m. Based on this assumption precise conditions are given under which the Bonferroni correction with nominal Family Wise Error Rate (FWER) level alpha and the Benjamini- Hochberg procedure (BH) at FDR level alpha are asymptotically optimal. When n is proportional to log m then alpha can remain fixed, whereas when n increases to infinity at a quicker rate, then alpha has to converge to zero roughly like n^(-1/2). Under these conditions the Bonferroni correction is ABOS in case of extreme sparsity, while BH adapts well to the unknown level of sparsity. In the second part of this article these optimality results are carried over to model selection in the context of multiple regression with orthogonal regressors. Several modifications of Bayesian Information Criterion are considered, controlling either FWER or FDR, and conditions are provided under which these selection criteria are ABOS. Finally the performance of these criteria is examined in a brief simulation study.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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