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arXiv 1002.3501math.STstat.TH
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稀疏性下多重检验过程的渐近Bayes最优性

Asymptotic Bayes-optimality under sparsity of some multiple testing procedures

Małgorzata Bogdan, Arijit Chakrabarti, Florian Frommlet, Jayanta K. Ghosh

摘要:

在贝叶斯决策理论的框架内,我们研究了一个大类的多个测试规则的渐近最优性性质。一个参数设置被认为是,其中的观察来自一个正常的规模混合模型和总损失被假定为单个测试的损失之和。我们的模型可用于测试点零假设,以及区分大信号从众多非常小的影响。如果在我们选择的渐近框架内,规则的贝叶斯风险和贝叶斯预言(最小化贝叶斯风险的规则)的比率收敛于1,则规则被定义为稀疏下渐近贝叶斯最优(ABOS)。我们的主要兴趣是在渐近计划中的比例p的“真”的替代品收敛到零。我们充分刻画类固定阈值多重测试规则,这是ABOS,从而推导出控制贝叶斯错误发现率(BFDR)的规则的渐近最优性的条件。最后,我们提供的条件下,流行的Benjamini-Hochberg(BH)和Bonferroni程序是ABOS,并表明,对于广泛的一类稀疏水平,前者的阈值可以近似为一个非随机阈值。

英文摘要:

Within a Bayesian decision theoretic framework we investigate some asymptotic optimality properties of a large class of multiple testing rules. A parametric setup is considered, in which observations come from a normal scale mixture model and the total loss is assumed to be the sum of losses for individual tests. Our model can be used for testing point null hypotheses, as well as to distinguish large signals from a multitude of very small effects. A rule is defined to be asymptotically Bayes optimal under sparsity (ABOS), if within our chosen asymptotic framework the ratio of its Bayes risk and that of the Bayes oracle (a rule which minimizes the Bayes risk) converges to one. Our main interest is in the asymptotic scheme where the proportion p of "true" alternatives converges to zero. We fully characterize the class of fixed threshold multiple testing rules which are ABOS, and hence derive conditions for the asymptotic optimality of rules controlling the Bayesian False Discovery Rate (BFDR). We finally provide conditions under which the popular Benjamini-Hochberg (BH) and Bonferroni procedures are ABOS and show that for a wide class of sparsity levels, the threshold of the former can be approximated by a nonrandom threshold.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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