离子束辐射损伤的多尺度研究：复合DNA损伤和热尖峰效应
Multiscale approach to radiation damage induced by ion beams: complex DNA damage and effects of thermal spikes
摘要：
我们提出的多尺度方法的最新进展，辐射损伤所造成的组织与高能离子的照射，并报告复杂的DNA损伤的计算和生物分子上的热尖峰的影响的最新进展。多尺度方法旨在量化离子辐照期间和之后发生的最重要的物理、化学和生物现象，并为临床必要的计算提供更好的方法，具有足够的准确性。我们提出了一种方法来量化复杂的集群损伤，由离子引起的辐射损伤的最重要的功能之一。该方法可用于计算不可修复的DNA损伤。我们包括热尖峰，预测发生在组织中的短时间后，离子的通道附近的离子的轨道在我们以前的工作，到建模的热环境的分子动力学分析泛素和讨论这些模拟的第一个结果。
英文摘要：
We present the latest advances of the multiscale approach to radiation damage caused by irradiation of a tissue with energetic ions and report the most recent advances in the calculations of complex DNA damage and the effects of thermal spikes on biomolecules. The multiscale approach aims to quantify the most important physical, chemical, and biological phenomena taking place during and following irradiation with ions and provide a better means for clinically-necessary calculations with adequate accuracy. We suggest a way of quantifying the complex clustered damage, one of the most important features of the radiation damage caused by ions. This method can be used for the calculation of irreparable DNA damage. We include thermal spikes, predicted to occur in tissue for a short time after ion's passage in the vicinity of the ions' tracks in our previous work, into modeling of the thermal environment for molecular dynamics analysis of ubiquitin and discuss the first results of these simulations.
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