静止:逃避药物对细胞群影响的机制
Quiescence: a mechanism for escaping the effects of drug on cell populations
摘要:
我们指出,一个简单而通用的策略,以降低灭绝的风险,包括在发展一个休眠阶段,其中生物体是无法繁殖,但可能会死亡。这种休眠的有机体受到保护,免受有毒环境的侵害。其结果是通过引入一种零繁殖适应度来增加整个种群的生存概率。这是可能的,因为休眠个体的储存库可以作为缓冲,可以缓冲出生和死亡数量的致命波动,如果没有休眠种群,整个种群就会灭绝。
英文摘要:
We point out that a simple and generic strategy to lower the risk for extinction consists in the developing a dormant stage in which the organism is unable to multiply but may die. The dormant organism is protected against the poisonous environment. The result is to increase the survival probability of the entire population by introducing a type of zero reproductive fitness. This is possible, because the reservoir of dormant individuals act as a buffer that can cushion fatal fluctuations in the number of births and deaths which without the dormant population would have driven the entire population to extinction.
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