光动力疗法对肿瘤免疫的影响
Photodynamic therapy influence on anti-cancer immunity
摘要：
系统的偏微分方程描述肿瘤免疫动力学血管生成考虑。对于空间均质情况，进行了模型的稳态分析。数值模拟了单次光动力学碰撞效应。在免疫反应较强的情况下，我们发现光动力疗法（PDT）可使肿瘤体积显著缩小，并伴有白细胞介素2浓度的增加。相反，弱免疫应答的光动力刺激显示不足以减少肿瘤。这些发现表明，抗肿瘤免疫应答在PDT后的长期肿瘤控制中的重要作用。
英文摘要：
The system of partial differential equations describing tumor-immune dynamics with angiogenesis taken into account is presented. For spatially homogeneous case, the steady state analysis of the model is carried out. The effects of single photodynamic impact are numerically simulated. In the case of strong immune response we found that the photodynamic therapy (PDT) gives rise to the substantial shrinkage of tumor size which is accompanied by the increase of interleukin-2 concentration. On the contrary, the photodynamic stimulation of weak immune response is shown to be insufficient to reduce the tumor. These findings indicate the important role of anti-cancer immune response in the long-term tumor control after PDT.
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