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arXiv 0910.1970math.DSq-bio.NC
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一个模型爆发神经元的相位响应分析

Dissecting the Phase Response of a Model Bursting Neuron

William Erik Sherwood, John Guckenheimer

摘要:

我们研究了神经元爆发的Hindmarsh-Rose模型的相位响应特性,使用了无限小扰动近似和直接模拟突触输入计算的爆发相位响应曲线(BPRCs)。由此产生的BPRCs有一个显着更复杂的结构比通常的I型和II型PRCs的尖峰神经元模型,他们表现出高度的时间敏感性变化的尖峰脉冲的数量,导致大幅度的相位响应。我们使用快,慢解剖和等时线计算分析的相位响应动力学在弱和强扰动制度。

英文摘要:

We investigate the phase response properties of the Hindmarsh-Rose model of neuronal bursting using burst phase response curves (BPRCs) computed with an infinitesimal perturbation approximation and by direct simulation of synaptic input. The resulting BPRCs have a significantly more complicated structure than the usual Type I and Type II PRCs of spiking neuronal models, and they exhibit highly timing-sensitive changes in the number of spikes per burst that lead to large magnitude phase responses. We use fast-slow dissection and isochron calculations to analyze the phase response dynamics in both weak and strong perturbation regimes.

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