同源结构域残基中存在pKa扰动促进DNA结合
Presence of pKa Perturbations Among Homeodomain Residues Facilitates DNA Binding
摘要：
含有同源结构域的蛋白质是一大类DNA结合蛋白，据信其主要起转录因子的作用。静电相互作用已被证明是至关重要的同源结构域的结合到DNA。DNA磷酸结合中涉及的同源结构域残基的静电状态的检查已经证明了保守的存在下向上移动的pKa值之间的赖氨酸和精氨酸的基本残基。据信，这些pKa扰动有助于与DNA结合，因为它们确保碱性残基始终保持正电荷。
英文摘要：
Homeodomain containing proteins are a broad class of DNA binding proteins that are believed to primarily function as transcription factors. Electrostatics interactions have been demonstrated to be critical for the binding of the homeodomain to DNA. An examination of the electrostatic state of homeodomain residues involved in DNA phosphate binding has demonstrated the conserved presence of upward shifted pKa values among the basic residue of lysine and arginine. It is believed that these pKa perturbations work to facilitate binding to DNA since they ensure that the basic residues always retain a positive charge.
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