蛋白质静电与HCV和HIV复制蛋白进化的相互关系
Interrelationship Between Protein Electrostatics and Evolution in HCV and HIV Replicative Proteins
摘要：
蛋白质静电已被证明在蛋白质功能中起着至关重要的作用，许多功能上重要的氨基酸残基表现出与正常氨基酸残基不同的静电状态。具有改变的静电状态的残基可以通过存在被2个或更多个pK单位扰动的pKa值来鉴定，并且已经证明这些残基在催化、配体结合和蛋白质稳定性中起关键作用。在HCV解旋酶和聚合酶，以及HIV逆转录酶，高度保守的区域被证明拥有更大的数量和幅度的扰动比保守程度较低的区域，这表明有一个相互关系存在蛋白质静电和进化之间。
英文摘要：
Protein electrostatics have been demonstrated to play a vital role in protein functionality, with many functionally important amino acid residues exhibiting an electrostatic state that is altered from that of a normal amino acid residue. Residues with altered electrostatic states can be identified by the presence of a pKa value that is perturbed by 2 or more pK units, and such residues have been demonstrated to play critical roles in catalysis, ligand binding, and protein stability. Within the HCV helicase and polymerase, as well as the HIV reverse transcriptase, highly conserved regions were demonstrated to possess a greater number and magnitude of perturbations than lesser conserved regions, suggesting that there is an interrelationship present between protein electrostatics and evolution.
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