收缩预应力控制活细胞对大的外力的反应中的硬化和流化
Contractile prestress controls stiffening and fluidization of living cells in response to large external forces
摘要：
我们报告的同时表征的时间和力依赖性的机械性能的粘附细胞在生理相关制度的大的力量。我们使用磁性镊子对与细胞骨架结合的磁珠施加力，并记录所产生的变形（蠕变响应）。蠕变响应遵循弱幂律在所有的力水平。应力硬化和流化同时发生，并量化的力依赖性的蠕变柔量和幂律指数。硬化和流体化的量，在响应力的细胞的收缩预应力控制，并遵循一个简单的关系。这种行为在涉及细胞与其环境之间的机械相互作用的生物过程中可能具有根本的重要性。
英文摘要：
We report the simultaneous characterization of time- and force-dependent mechanical properties of adherent cells in the physiologically relevant regime of large forces. We used magnetic tweezers to apply forces to magnetic beads bound to the cytoskeleton, and recorded the resulting deformation (creep response). The creep response followed a weak power law at all force levels. Stress stiffening and fluidization occurred simultaneously and were quantified by the force-dependence of the creep compliance and the power law exponent. The amount of stiffening and fluidization in response to force was controlled solely by the contractile prestress of the cell and followed a simple relationship. This behavior may be of fundamental importance in biological processes that involve a mechanical interaction between cells and their environment.
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