细胞集体流动性控制细胞-细胞外基质组织中的主动预应力传递
Collective Cell Fluidity Controls Active Prestress Transmission in Cell-Extracellular-Matrix Tissues
浏览论文内容
中文总结 AI 辅助
该研究开发三维细观力学模型，揭示细胞集体流动性通过细胞-基质界面的组织与传递持久性，控制组织主动预应力及宏观刚度，类固体与类流体簇的力传递特性存在差异。
中文摘要 AI 辅助
组织是活性复合材料，其中多细胞集体与细胞外基质会发生力学重组。我们开发了一种三维细观力学模型，该模型通过动态的力生成界面将可变形、可重排的细胞簇与半柔性纤维的无序网络耦合在一起。细胞簇被表示为类固体或类流体的顶点模型球体，并通过被动或收缩连接体与基质耦合，这些连接体随细胞簇边界的重排而更新。我们设置了匹配的完整组、空白组和被动连接体对照组，以分别研究空腔形成、界面系链和主动加载的作用。在小应变下，被动系链提供适度增强，而主动收缩会使基质产生预应力并显著使其变硬；类固体簇可保持连贯的力传递，在活性、簇大小和簇数量变化时，其过量模量按|σ|^1.4的比例缩放；类流体簇经历更频繁的界面更新，导致预应力与刚度之间的耦合更弱且呈非单调关系；增加簇数量会在预应力区域通过足够持久的界面连接时产生集体变硬效应。在大应变下，类固体和类流体系统均会因残留纤维主干成为力学主导而趋近于对应的空白网络响应。因此，细胞产生的预应力仅在与细胞-基质界面的组织及其传递持久性共同作用时才会控制宏观刚度。
英文摘要
Tissues are active composites in which multicellular collectives and extracellular matrices mechanically reorganize one another. We develop a three-dimensional micromechanical model that couples deformable, rearranging cell clusters to a disordered network of semiflexible fibers through a dynamic, force-generating interface. Cell clusters are represented as solid-like or fluid-like vertex-model spheroids and coupled to the matrix by passive or contractile linkers renewed as the cluster boundary reorganizes. Matched intact, voided, and passive-linker controls separate cavity formation, interfacial tethering, and active loading. At small strain, passive tethering provides modest reinforcement, whereas active contraction prestresses and strongly stiffens the matrix. Solid-like clusters preserve coherent force transmission and exhibit an excess modulus scaling approximately as $|σ|^{1.4}$ across changes in activity, cluster size, and cluster number. Fluid-like clusters undergo greater interfacial renewal, producing weaker and nonmonotonic coupling between prestress and stiffness. Increasing cluster number produces collective stiffening when prestressed regions become connected through sufficiently persistent interfaces. At large strain, both solid-like and fluid-like systems approach the corresponding voided-network response as the residual fiber backbone becomes mechanically dominant. Thus, cell-generated prestress controls macroscopic stiffness only together with the organization and persistence of its transmission across the cell-matrix interface.
发表机构
- School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University（上海交通大学化学化工学院）
- Physics Department, Syracuse University（雪城大学物理系）
- Indian Creek Farm（印度溪农场）
机构由 AI 辅助整理，请以论文原文为准。
