代谢途径的随机控制
Stochastic Control of Metabolic Pathways
摘要：
我们研究了外在噪声在代谢网络中的作用。我们在动力学水平上引入外部随机波动，并展示这些如何导致标准代谢控制分析的随机推广。虽然求和和连通性定理在存在外部噪声的情况下成立，但控制系数通过对噪声强度的显式依赖来结合其效果。新的弹性和响应系数也被定义。因此，噪声控制的概念被引入作为调节代谢系统行为的一种方式。我们认为，这个框架也适用于固有噪声，当时间尺度分离存在于系统中。
英文摘要：
We study the effect of extrinsic noise in metabolic networks. We introduce external random fluctuations at the kinetic level, and show how these lead to a stochastic generalization of standard Metabolic Control Analysis. While Summation and Connectivity Theorems hold true in presence of extrinsic noise, control coefficients incorporate its effect through an explicit dependency on the noise intensity. New elasticities and response coefficients are also defined. Accordingly, the concept of control by noise is introduced as a way of tuning the systemic behaviour of metabolisms. We argue that this framework holds for intrinsic noise too, when time-scale separation is present in the system.
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