基于多智能体系统的线粒体代谢模拟
Simulation of mitochondrial metabolism using multi-agents system
摘要：
代谢途径描述酶促反应链。它们的建模是理解生命系统的关键点。酶促反应是一种或几种代谢物（底物）和酶（简单蛋白质或几个亚基的酶复合物）之间的相互作用。在我们的线粒体在Silico项目，线粒体，我们研究线粒体的代谢，细胞内的细胞器。许多常微分方程模型可在文献中。它们很好地拟合了代谢途径内通量值的实验结果，但$\pm$难以用这样的模型转录许多参数：酶的定位、反应调度规则等。此外，线粒体代谢的重要部分的模型可能变得非常复杂，包含50多个方程。在这种情况下，多代理系统出现作为替代模型的代谢途径。首先，我们关注膜设计。线粒体是一个特殊的情况，因为内部线粒体空间，即基质空间，是由两个膜界定的：内部和外部。除了基质酶之外，其他酶位于膜内或膜间隙中。线粒体代谢的分析必须考虑到这种结构。
英文摘要：
Metabolic pathways describe chains of enzymatic reactions. Their modelling is a key point to understand living systems. An enzymatic reaction is an interaction between one or several metabolites (substrates) and an enzyme (simple protein or enzymatic complex build of several subunits). In our Mitochondria in Silico Project, MitoScop, we study the metabolism of the mitochondria, an intra-cellular organelle. Many ordinary differential equation models are available in the literature. They well fit experimental results on flux values inside the metabolic pathways, but many parameters are di$\pm$cult to transcribe with such models: localization of enzymes, rules about the reactions scheduler, etc Moreover, a model of a significant part of mitochondrial metabolism could become very complex and contain more than 50 equations. In this context, the multi-agents systems appear as an alternative to model the metabolic pathways. Firstly, we have looked after membrane design. The mitochondria is a particular case because the inner mitochondrial space, ie matricial space, is delimited by two membranes: the inner and the outer one. In addition to matricial enzymes, other enzymes are located inside the membranes or in the inter-membrane space. Analysis of mitochondrial metabolism must take into account this kind of architecture.
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