系统发生树的随机模型
A stochastic model for phylogenetic trees
摘要:
我们提出了以下简单的随机模型的系统发生树。新的类型是根据生死链出生和死亡。在每次出生时,我们将适应度与从固定分布中采样的新类型相关联。在每次死亡时,具有最小适应度的类型被杀死。我们表明,如果出生(即突变)率是亚临界的,我们得到一个系统发育树一致的流感树(在任何给定的时间和一个占主导地位的类型持续很长一段时间的几种类型)。当出生率处于超临界状态时,我们得到的系统发育树与HIV树一致(在任何给定时间都有许多类型,但没有一种持续很长时间)。
英文摘要:
We propose the following simple stochastic model for phylogenetic trees. New types are born and die according to a birth and death chain. At each birth we associate a fitness to the new type sampled from a fixed distribution. At each death the type with the smallest fitness is killed. We show that if the birth (i.e. mutation) rate is subcritical we get a phylogenetic tree consistent with an influenza tree (few types at any given time and one dominating type lasting a long time). When the birth rate is supercritical we get a phylogenetic tree consistent with an HIV tree (many types at any given time, none lasting very long).
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