The accuracy of a diagnostic test is typically characterised using the receiver operating characteristic (ROC) curve. Summarising indexes such as the area under the ROC curve (AUC) are used to compare different tests as well as to measure the difference between two populations. Often additional information is available on some of the covariates which are known to influence the accuracy of such measures. We propose nonparametric methods for covariate adjustment of the AUC. Models with normal errors and non-normal errors are discussed and analysed separately. Nonparametric regression is used for estimating mean and variance functions in both scenarios. In the general noise case we propose a covariate-adjusted Mann-Whitney estimator for AUC estimation which effectively uses available data to construct working samples at any covariate value of interest and is computationally efficient for implementation. This provides a generalisation of the Mann-Whitney approach for comparing two populations by taking covariate effects into account. We derive asymptotic properties for the AUC estimators in both settings, including asymptotic normality, optimal strong uniform convergence rates and MSE consistency. The usefulness of the proposed methods is demonstrated through simulated and real data examples.
We analyze the statistical properties of nonparametric regression estimators using covariates which are not directly observable, but have be estimated from data in a preliminary step. These so-called generated covariates appear in numerous applications, including two-stage nonparametric regression, estimation of simultaneous equation models or censored regression models. Yet so far there seems to be no general theory for their impact on the final estimator's statistical properties. Our paper provides such results. We derive a stochastic expansion that characterizes the influence of the generat…
In this paper, a nonparametric estimator is proposed for estimating the L1-median for multivariate conditional distribution when the covariates take values in an infinite dimensional space. The multivariate case is more appropriate to predict the components of a vector of random variables simultaneously rather than predicting each of them separately. While estimating the conditional L1-median function using the well-known Nadarya-Waston estimator, we establish the strong consistency of this estimator as well as the asymptotic normality. We also present some simulations and provide how to built…
We consider nonparametric estimation of a regression curve when the data are observed with multiplicative distortion which depends on an observed confounding variable. We suggest several estimators, ranging from a relatively simple one that relies on restrictive assumptions usually made in the literature, to a sophisticated piecewise approach that involves reconstructing a smooth curve from an estimator of a constant multiple of its absolute value, and which can be applied in much more general scenarios. We show that, although our nonparametric estimators are constructed from predictors of the…
The main purpose is to estimate the regression function of a real random variable with functional explanatory variable by using a recursive nonparametric kernel approach. The mean square error and the almost sure convergence of a family of recursive kernel estimates of the regression function are derived. These results are established with rates and precise evaluation of the constant terms. Also, a central limit theorem for this class of estimators is established. The method is evaluated on simulations and real data set studies.
We present a nonparametric family of estimators for the tail index of a Pareto-type distribution when covariate information is available. Our estimators are based on a weighted sum of the log-spacings between some selected observations. This selection is achieved through a moving window approach on the covariate domain and a random threshold on the variable of interest. Asymptotic normality is proved under mild regularity conditions and illustrated for some weight functions. Finite sample performances are presented on a real data study.
University of Chicago（芝加哥大学）；UC Berkeley（加州大学伯克利分校）
We study covariate shift in the context of nonparametric regression. We introduce a new measure of distribution mismatch between the source and target distributions that is based on the integrated ratio of probabilities of balls at a given radius. We use the scaling of this measure with respect to the radius to characterize the minimax rate of estimation over a family of Hölder continuous functions under covariate shift. In comparison to the recently proposed notion of transfer exponent, this measure leads to a sharper rate of convergence and is more fine-grained. We accompany our theory with …
In this paper we propose a general class of covariate-adjusted response-adaptive (CARA) designs based on a new functional urn model. We prove strong consistency concerning the functional urn proportion and the proportion of subjects assigned to the treatment groups, in the whole study and for each covariate profile, allowing the distribution of the responses conditioned on covariates to be estimated nonparametrically. In addition, we establish joint central limit theorems for the above quantities and the sufficient statistics of features of interest, which allow to construct procedures to make…
In this paper, we consider a weighted local linear estimator based on the inverse selection probability for nonparametric regression with missing covariates at random. The asymptotic distribution of the maximal deviation between the estimator and the true regression function is derived and an asymptotically accurate simultaneous confidence band is constructed. The estimator for the regression function is shown to be oracally efficient in the sense that it is uniformly indistinguishable from that when the selection probabilities are known. Finite sample performance is examined via simulation st…
We consider inference for the mean and covariance functions of covariate adjusted functional data using Local Linear Kernel (LLK) estimators. By means of a double asymptotic, we differentiate between sparse and dense covariate adjusted functional data - depending on the relative order of m (the discretization points per function) and n (the number of functions). Our simulation results demonstrate that the existing asymptotic normality results can lead to severely misleading inferences in finite samples. We explain this phenomenon based on our theoretical results and propose finite-sample corre…
Semiparametric single-index assumptions are convenient and widely used dimen\-sion reduction approaches that represent a compromise between the parametric and fully nonparametric models for regressions or conditional laws. In a mean regression setup, the SIM assumption means that the conditional expectation of the response given the vector of covariates is the same as the conditional expectation of the response given a scalar projection of the covariate vector. In a conditional distribution modeling, under the SIM assumption the conditional law of a response given the covariate vector coincide…
Continuous biomarkers are common for disease screening and diagnosis. To reach a dichotomous clinical decision, a threshold would be imposed to distinguish subjects with disease from non-diseased individuals. Among various performance metrics for a continuous biomarker, specificity at a controlled sensitivity level (or vice versa) is often desirable for clinical utility since it directly targets where the clinical test is intended to operate. Covariates, such as age, race, and sample collection, could impact the controlled sensitivity level in subpopulations and may also confound the associati…
A dimension reduction-based adaptive-to-model test is proposed for significance of a subset of covariates in the context of a nonparametric regression model. Unlike existing local smoothing significance tests, the new test behaves like a local smoothing test as if the number of covariates were just that under the null hypothesis and it can detect local alternatives distinct from the null at the rate that is only related to the number of covariates under the null hypothesis. Thus, the curse of dimensionality is largely alleviated when nonparametric estimation is inevitably required. In the case…
The Welch-Satterthwaite t-test is one of the most prominent and often used statistical inference method in applications. The method is, however, not flexible with respect to adjustments for baseline values or other covariates, which may impact the response variable. Existing analysis of covariance methods are typically based on the assumption of equal variances across the groups. This assumption is hard to justify in real data applications and the methods tend to not control the type-1 error rate satisfactorily under variance heteroscedasticity. In the present paper, we tackle this problem and…
We investigate nonparametric regression methods based on spatial depth and quantiles when the response and the covariate are both functions. As in classical quantile regression for finite dimensional data, regression techniques developed here provide insight into the influence of the functional covariate on different parts, like the center as well as the tails, of the conditional distribution of the functional response. Depth and quantile based nonparametric regressions are useful to detect heteroscedasticity in functional regression. We derive the asymptotic behaviour of nonparametric depth a…
Randomized block factorial experiments are widely used in industrial engineering, clinical trials, and social science. Researchers often use a linear model and analysis of covariance to analyze experimental results; however, limited studies have addressed the validity and robustness of the resulting inferences because assumptions for a linear model might not be justified by randomization in randomized block factorial experiments. In this paper, we establish a new finite population joint central limit theorem for usual (unadjusted) factorial effect estimators in randomized block $2^K$ factorial…
Consider the task of matrix estimation in which a dataset $X \in \mathbb{R}^{n\times m}$ is observed with sparsity $p$, and we would like to estimate $\mathbb{E}[X]$, where $\mathbb{E}[X_{ui}] = f(α_u, β_i)$ for some Holder smooth function $f$. We consider the setting where the row covariates $α$ are unobserved yet the column covariates $β$ are observed. We provide an algorithm and accompanying analysis which shows that our algorithm improves upon naively estimating each row separately when the number of rows is not too small. Furthermore when the matrix is moderately proportioned, our algorit…
When estimating a Global Average Treatment Effect (GATE) under network interference, units can have widely different relationships to the treatment depending on a combination of the structure of their network neighborhood, the structure of the interference mechanism, and how the treatment was distributed in their neighborhood. In this work, we introduce a sequential procedure to generate and select graph- and treatment-based covariates for GATE estimation under regression adjustment. We show that it is possible to simultaneously achieve low bias and considerably reduce variance with such a pro…
Identifying a biomarker or treatment-dose threshold that marks a specified level of risk is an important problem, especially in clinical trials. This risk, viewed as a function of thresholds and possibly adjusted for covariates, we call the threshold-response function. Extending the work of Donovan, Hudgens and Gilbert (2019), we propose a nonparametric efficient estimator for the covariate-adjusted threshold-response function, which utilizes machine learning and Targeted Minimum-Loss Estimation (TMLE). We additionally propose a more general estimator, based on sequential regression, that also…
Towards Best Practices for Covariate Adjustment in Regulatory Trials: From Fixed to Data-Adaptive Approaches
University of California Berkeley（加州大学伯克利分校）；Division of Biometrics IV, OB/OTS/CDER/FDA（美国食品药品监督管理局药物评价与研究中心生物统计学第四处）；Harvard T.H. Chan School of Public Health（哈佛大学陈曾熙公共卫生学院）；Beth Israel Deaconess Hospital（贝斯以色列女执事医疗中心）；Novo Nordisk A/S（诺和诺德公司）；Pfizer Inc.（辉瑞公司）；Northeastern University（东北大学）；Gilead Sciences（吉利德科学公司）；National Center for the Advancement of Translational Science, National Institutes of Health（美国国立卫生研究院转化科学促进国家中心）；Section of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark（南丹麦大学流行病学、生物统计学和生物人口学系）；Forum for Collaborative Research, School of Public Health, University of California Berkeley（加州大学伯克利分校公共卫生学院合作研究论坛）；OncoBrain Inc（OncoBrain 公司）；Moffitt Cancer Center（莫菲特癌症中心）；Department of Biostatistics, University of Michigan（密歇根大学生物统计学系）；Department of Mathematics, Computer Science and Statistics, Ghent University（根特大学数学、计算机科学和统计系）；Department of Mathematics and Data Science, Vrije Universiteit Brussel（布鲁塞尔自由大学数学与数据科学系）
Adaptive deep nonparametric regression from dependent data under covariate shift
Université Jean Monnet, ICJ UMR5208, CNRS, Ecole Centrale de Lyon, INSA Lyon, Universite Claude Bernard Lyon 1（里昂 Jean Monnet 大学，ICJ UMR5208，国家科学研究中心，里昂中央理工大学，里昂国家理工学校，里昂大学 Claude Bernard 1）
Shape-Preserving Covariate Adjustment via Empirical Likelihood in Randomized Experiment
Zhejiang University of Finance and Economics（浙江财经大学）；University of Wisconsin, Madison（威斯康星大学麦迪逊分校）；University of Washington（华盛顿大学）；Eli Lilly and Company（礼来公司）
We consider the problem of estimating and inferring treatment effects in randomized experiments. In practice, stratified randomization, or more generally, covariate-adaptive randomization, is routinely used in the design stage to balance the treatment allocations with respect to a few variables that are most relevant to the outcomes. Then, regression is performed in the analysis stage to adjust the remaining imbalances to yield more efficient treatment effect estimators. Building upon and unifying the recent results obtained for ordinary least squares adjusted estimators under covariate-adapti…
The split-plot design arises from agricultural sciences with experimental units, also known as subplots, nested within groups known as whole plots. It assigns the whole-plot intervention by a cluster randomization at the whole-plot level and assigns the subplot intervention by a stratified randomization at the subplot level. The randomization mechanism guarantees covariate balance on average at both the whole-plot and subplot levels, and ensures consistent inference of the average treatment effects by the Horvitz--Thompson and Hajek estimators. However, covariate imbalance often occurs in fini…
We develop finite-population asymptotic theory for covariate adjustment in randomization-based causal inference for 2K factorial designs. In particular, we confirm that both the unadjusted and covariate-adjusted estimators of the factorial effects are asymptotically normal, and the latter is more precise than the former.
This paper is concerned with modeling the dependence structure of two (or more) time-series in the presence of a (possible multivariate) covariate which may include past values of the time series. We assume that the covariate influences only the conditional mean and the conditional variance of each of the time series but the distribution of the standardized innovations is not influenced by the covariate and is stable in time. The joint distribution of the time series is then determined by the conditional means, the conditional variances and the marginal distributions of the innovations, which …
Determining the relevant spatial covariates is one of the most important problems in the analysis of point patterns. Parametric methods may lead to incorrect conclusions, especially when the model of interactions between points is wrong. Therefore, we propose a fully nonparametric approach to testing significance of a covariate, taking into account the possible effects of nuisance covariates. Our tests match the nominal significance level, and their powers are comparable with the powers of parametric tests in cases where both the model for intensity function and the model for interactions are …
The Regression Discontinuity (RD) design is a widely used non-experimental method for causal inference and program evaluation. While its canonical formulation only requires a score and an outcome variable, it is common in empirical work to encounter RD analyses where additional variables are used for adjustment. This practice has led to misconceptions about the role of covariate adjustment in RD analysis, from both methodological and empirical perspectives. In this chapter, we review the different roles of covariate adjustment in RD designs, and offer methodological guidance for its correct us…
We investigate testing of the hypothesis of independence between a covariate and the marks in a marked point process. It would be rather straightforward if the (unmarked) point process were independent of the covariate and the marks. In practice, however, such an assumption is questionable and possible dependence between the point process and the covariate or the marks may lead to incorrect conclusions. Therefore, we propose to investigate the complete dependence structure in the triangle points--marks--covariates together. We take advantage of the recent development of the nonparametric rando…
