中性空间的调控网络和连通分量
Regulatory networks and connected components of the neutral space
摘要：
活细胞的功能在很大程度上由其调控网络的结构决定，该网络包括调控基因之间的非线性相互作用。这种监管系统的稳定性和可演变性的一个重要因素是中立性-通常大量的备选网络结构会产生必要的动态。在这里，我们研究了酵母细胞周期的离散化调控动力学[Li et al.，PNAS，2004]和能够复制它的网络集合，我们称之为功能性。其中，经验酵母野生型网络是接近最佳的稀疏布线。在建立或删除单个相互作用的点突变下，功能网络的中性空间被分割成4.7 * 10^8个分量。其中一个较小的包含野生型网络。平均而言，从野生型突变可达的功能网络是稀疏的，具有更高的噪声弹性和更少的固定点吸引子相比，该野生型组件之外的网络。
英文摘要：
The functioning of a living cell is largely determined by the structure of its regulatory network, comprising non-linear interactions between regulatory genes. An important factor for the stability and evolvability of such regulatory systems is neutrality - typically a large number of alternative network structures give rise to the necessary dynamics. Here we study the discretized regulatory dynamics of the yeast cell cycle [Li et al., PNAS, 2004] and the set of networks capable of reproducing it, which we call functional. Among these, the empirical yeast wildtype network is close to optimal with respect to sparse wiring. Under point mutations, which establish or delete single interactions, the neutral space of functional networks is fragmented into 4.7 * 10^8 components. One of the smaller ones contains the wildtype network. On average, functional networks reachable from the wildtype by mutations are sparser, have higher noise resilience and fewer fixed point attractors as compared with networks outside of this wildtype component.
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