人类micro-RNA共靶点网络模块
Modules of human micro-RNA co-target network
摘要：
人类微小RNA（microRNAs，miRNAs）靶向约90%的编码基因，形成复杂的调控网络。研究了以miRNA为节点，通过加权链接连接的miRNA共靶网络的社团结构。连接一对miRNA的连接的重量表示该对靶向的共同转录物的总数。我们认为该网络由大约74个模块组成，与之前获得的组件（或集群）非常相似[Online J Bioinformatics，10，280]，表明miRNA共同靶点网络的组件是自组织的，以最大化模块化。
英文摘要：
Human micro RNAs (miRNAs) target about 90% of the coding genes and form a complex regulatory network. We study the community structure of the miRNA co-target network considering miRNAs as the nodes which are connected by weighted links. The weight of link that connects a pair of miRNAs denote the total number of common transcripts targeted by that pair. We argue that the network consists of about 74 modules, quite similar to the components (or clusters) obtained earlier [Online J Bioinformatics, 10,280 ], indicating that the components of the miRNA co-target network are self organized in a way to maximize the modularity.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
