噪声对DNA横向电子传递测序的影响
Effect of Noise on DNA Sequencing via Transverse Electronic Transport
摘要：
先前的理论研究已经表明，当DNA链移位通过纳米孔或通道时，测量跨DNA链的横向电流可以提供DNA碱基的统计学上可区分的特征，并且因此可以允许快速DNA测序。然而，环境的波动，如离子和DNA运动，引入了重要的散射过程，可能会影响这种测序方法的可行性。为了理解这个问题，我们分析了一个简单的模型，该模型捕捉了这种复杂环境在电子退相中的作用及其从载流状态中去除载流子的能力。我们发现，这些影响并不强烈影响电流分布，由于非共振隧穿通过核苷酸的性质-结果，我们预计是一个共同的特点，在分子结中的运输。特别是，只有大的散射强度，相比分子状态和费米能级之间的能量间隙，显着改变的形式的电流分布。由于这个间隙本身是相当大的，电流分布保持保护免受这种类型的噪声，进一步支持使用横向电子输运测量的可能性DNA测序。
英文摘要：
Previous theoretical studies have shown that measuring the transverse current across DNA strands while they translocate through a nanopore or channel may provide a statistically distinguishable signature of the DNA bases, and may thus allow for rapid DNA sequencing. However, fluctuations of the environment, such as ionic and DNA motion, introduce important scattering processes that may affect the viability of this approach to sequencing. To understand this issue, we have analyzed a simple model that captures the role of this complex environment in electronic dephasing and its ability to remove charge carriers from current-carrying states. We find that these effects do not strongly influence the current distributions due to the off-resonant nature of tunneling through the nucleotides - a result we expect to be a common feature of transport in molecular junctions. In particular, only large scattering strengths, as compared to the energetic gap between the molecular states and the Fermi level, significantly alter the form of the current distributions. Since this gap itself is quite large, the current distributions remain protected from this type of noise, further supporting the possibility of using transverse electronic transport measurements for DNA sequencing.
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