基因表达和蛋白质生产中的探测噪声
Probing Noise in Gene Expression and Protein Production
摘要:
我们推导出精确的解决方案的简化模型的时间演化的细胞内的蛋白质浓度任意远离稳态。我们表明,监测的动态可以帮助建模和理解噪声的性质及其在基因表达和蛋白质生产中的作用。我们介绍了一种新的措施,细胞周转分布,它可以用来探测DNA转录成信使RNA的阶段。
英文摘要:
We derive exact solutions of simplified models for the temporal evolution of the protein concentration within a cell population arbitrarily far from the stationary state. We show that monitoring the dynamics can assist in modeling and understanding the nature of the noise and its role in gene expression and protein production. We introduce a new measure, the cell turnover distribution, which can be used to probe the phase of transcription of DNA into messenger RNA.
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