探索双态折叠的起源
Probing the Origins of Two-State Folding
摘要：
许多蛋白质系统以双态方式折叠。然而，随机模型很少显示双态动力学，因此这种行为不应被接受为默认行为。迄今为止，许多理论的流行两个国家的动力学已经提出，但没有充分解释的广度实验观察。一个模型，使最低限度的假设，提出两个国家的行为是可能的任何系统与一个压倒性的人口原生状态。我们表明，两个国家的折叠是紧急的，并加强了本机状态的占用人口的增加。此外，该模型表现出一个枢纽般的行为，与展开状态之间的缓慢相互转换。尽管如此，展开状态相对于折叠时间快速平衡。这个明显的悖论通过这个模型很容易理解。最后，我们的研究结果比较有利的蛋白质折叠率作为链长和Keq的函数的实验测量，并提供了新的见解这些结果。
英文摘要：
Many protein systems fold in a two-state manner. Random models, however, rarely display two-state kinetics and thus such behavior should not be accepted as a default. To date, many theories for the prevalence of two-state kinetics have been presented, but none sufficiently explain the breadth of experimental observations. A model, making a minimum of assumptions, is introduced that suggests two-state behavior is likely for any system with an overwhelmingly populated native state. We show two-state folding is emergent and strengthened by increasing the occupancy population of the native state. Further, the model exhibits a hub-like behavior, with slow interconversions between unfolded states. Despite this, the unfolded state equilibrates quickly relative to the folding time. This apparent paradox is readily understood through this model. Finally, our results compare favorable with experimental measurements of protein folding rates as a function of chain length and Keq, and provide new insight into these results.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
