肽和蛋白质聚集中的自模板成核
Self-Templated Nucleation in Peptide and Protein aggregation
摘要：
肽和蛋白质表现出组装成高度有序的纤维状聚集体的共同趋势，其形成以成核依赖的方式进行，通常在形成无序的低聚组装体之前。这一过程受到了广泛关注，因为无序的寡聚体聚集体与神经退行性疾病如阿尔茨海默病和帕金森病有关。在这里，我们描述了一个自模板成核机制，确定之间的过渡的多肽链的初始缩合成无序的组件和它们重新排序成纤维状结构。我们目前的结果表明，在分子水平上，这种转变是由于多肽链重新排序的低聚物成纤维状组件，其表面作为模板，稳定无序的组件内的能力。
英文摘要：
Peptides and proteins exhibit a common tendency to assemble into highly ordered fibrillar aggregates, whose formation proceeds in a nucleation-dependent manner that is often preceded by the formation of disordered oligomeric assemblies. This process has received much attention because disordered oligomeric aggregates have been associated with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Here we describe a self-templated nucleation mechanism that determines the transition between the initial condensation of polypeptide chains into disordered assemblies and their reordering into fibrillar structures. The results that we present show that at the molecular level this transition is due to the ability of polypeptide chains to reorder within oligomers into fibrillar assemblies whose surfaces act as templates that stabilise the disordered assemblies.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
