粗粒度动力学模型中DNA双链体的拉伸和扭曲
Stretching and twisting of the DNA duplexes in coarse grained dynamical models
摘要：
提出了三种粗粒度的双链DNA模型，并在机械操作的背景下，如扭曲和各种方案的拉伸进行比较。这些模型的不同之处在于代表每个核苷酸的有效珠粒的数量（在两个和五个之间）。它们都表现出类似的行为，特别是，导致定性与实验和全原子模拟一致的扭矩力相图。
英文摘要：
Three coarse-grained models of the double-stranded DNA are proposed and compared in the context of mechanical manipulation such as twisting and various schemes of stretching. The models differ in the number of effective beads (between two and five) representing each nucleotide. They all show similar behavior and, in particular, lead to a torque-force phase diagrams qualitatively consistent with experiments and all-atom simulations.
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