了解生物胶体的动力学，以阐明白内障形成的早期诊断方法的发展
Understanding the dynamics of biological colloids to elucidate cataract formation towards the development of methodology for its early diagnosis
摘要：
接目镜是哺乳动物组织中表现出复杂胶体行为的最典型的例子。在本文中，我们简要介绍了如何在胶体悬浮液中的动力学可以帮助解决晶状体白内障，这是最终相关的蛋白质自组装在病理条件下的选定方面。从动态光散射的接目镜匀浆在一个广泛的蛋白质浓度的结果进行了分析，并确定了各种松弛模式的集体和自扩散过程。使用此信息作为输入，完整晶状体核的复杂松弛模式被合理化。冷性白内障模型-晶状体细胞质在冷却下的相分离效应-用于在体外条件下模拟晶状体白内障，以确定可用作白内障发作的可靠指标的关联函数的参数。动态光散射作为一种非侵入性的，早期诊断工具的眼部疾病的适用性也证明了在本文件的调查结果的光。
英文摘要：
The eye lens is the most characteristic example of mammalian tissues exhibiting complex colloidal behaviour. In this paper we briefly describe how dynamics in colloidal suspensions can help addressing selected aspects of lens cataract which is ultimately related to the protein self-assembly under pathological conditions. Results from dynamic light scattering of eye lens homogenates over a wide protein concentration were analyzed and the various relaxation modes were identified in terms of collective and self-diffusion processes. Using this information as an input, the complex relaxation pattern of the intact lens nucleus was rationalized. The model of cold cataract - a phase separation effect of the lens cytoplasm with cooling - was used to simulate lens cataract at in vitro conditions in an effort to determine the parameters of the correlation functions that can be used as reliable indicators of the cataract onset. The applicability of dynamic light scattering as a non-invasive, early-diagnostic tool for ocular diseases is also demonstrated in the light of the findings of the present paper.
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