对白内障形成的新认识--通过相互吸引增强稳定性
New insight into cataract formation -- enhanced stability through mutual attraction
摘要：
小角中子散射实验和分子动力学模拟结合应用的概念，从软物质物理复杂的蛋白质混合物提供了新的见解接目镜蛋白质混合物的稳定性。探索这种胶体蛋白质的类比，我们证明了不同的蛋白质之间的弱吸引力有助于保持镜头的透明度在一个非常敏感和非单调的方式。这些结果不仅代表了一个重要的一步，更好地了解蛋白质凝聚疾病，如白内障的形成，但提供了一般的指导方针，调整胶体混合物的稳定性，一个主题相关的软物质物理和工业应用。
英文摘要：
Small-angle neutron scattering experiments and molecular dynamics simulations combined with an application of concepts from soft matter physics to complex protein mixtures provide new insight into the stability of eye lens protein mixtures. Exploring this colloid-protein analogy we demonstrate that weak attractions between unlike proteins help to maintain lens transparency in an extremely sensitive and non-monotonic manner. These results not only represent an important step towards a better understanding of protein condensation diseases such as cataract formation, but provide general guidelines for tuning the stability of colloid mixtures, a topic relevant for soft matter physics and industrial applications.
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