频率依赖的化学定位与化学趋动目标选择
Frequency-dependent Chemolocation and Chemotactic Target Selection
AI总结：
本文提出一种时间依赖的趋化机制，通过化学信号传递实现目标选择，探讨了在单一和多个目标情况下，细胞如何根据化学信号强度和释放频率优化移动路径。
摘要：
趋化作用通常是在细胞向静态外源化学吸引源移动的背景下建模的。本文提出了一种时间依赖的趋化机制，其中自我推进的粒子（例如细胞）释放一种化学物质，该物质扩散到固定粒子（目标）并促使这些目标产生第二种化学物质。粒子随后沿着第二种化学物质的浓度梯度移动，类似于扩散回声定位。当只有一个目标存在时，我们描述了优化细胞移动到目标的探测释放策略。在多个目标存在的情况下，细胞选择的目标取决于强度，并且有趣的是，还取决于探测化学物质释放的频率。尽管涉及额外的化学信号步骤，我们的化学“pinging”假说允许在多个物理或生物实现中实现更灵活的目标选择调节。
英文摘要：
Chemotaxis is typically modeled in the context of cellular motion towards a static, exogenous source of chemoattractant. Here, we propose a time-dependent mechanism of chemotaxis in which a self-propelled particle ({\it e.g.}, a cell) releases a chemical that diffuses to fixed particles (targets) and signals the production of a second chemical by these targets. The particle then moves up concentration gradients of this second chemical, analogous to diffusive echolocation. When one target is present, we describe probe release strategies that optimize travel of the cell to the target. In the presence of multiple targets, the one selected by the cell depends on the strength and, interestingly, on the frequency of probe chemical release. Although involving an additional chemical signaling step, our chemical ``pinging'' hypothesis allows for greater flexibility in regulating target selection, as seen in a number of physical or biological realizations.
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