动物细胞间歇迁移的最佳趋化性
Optimal chemotaxis in animal cell intermittent migration
摘要：
动物细胞可以在不移动的情况下感知化学梯度，并且面临着向目标迁移的挑战，尽管目标位置上有噪声信息。在这里，我们讨论了最佳的搜索策略的追逐者，通过切换两个阶段的运动（“运行”和“翻滚”），在翻滚阶段重新定位自己对目标，并在运行阶段执行持久的随机行走。我们发现，追逐者的平均运行时间可以调整，以尽量减少目标捕捉时间或空间分散的追逐者。我们得到的分析结果的捕获时间和空间分散的运行时间翻滚时间的小和大的比例的限制，和缩放的最佳运行时间的法律。我们的研究结果对动物细胞迁移的最佳趋化策略具有重要意义。
英文摘要：
Animal cells can sense chemical gradients without moving, and are faced with the challenge of migrating towards a target despite noisy information on the target position. Here we discuss optimal search strategies for a chaser that moves by switching between two phases of motion ("run" and "tumble"), reorienting itself towards the target during tumble phases, and performing a persistent random walk during run phases. We show that the chaser average run time can be adjusted to minimize the target catching time or the spatial dispersion of the chasers. We obtain analytical results for the catching time and for the spatial dispersion in the limits of small and large ratios of run time to tumble time, and scaling laws for the optimal run times. Our findings have implications for optimal chemotactic strategies in animal cell migration.
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