利用博弈论研究肿瘤侵袭性的出现
Studying the emergence of invasiveness in tumours using game theory
摘要：
如果肿瘤要变成癌症，肿瘤细胞必须获得许多能力。这些关键能力之一是增加的运动性，这是入侵其他组织和转移所需的。本文提出了一个定性的数学模型的基础上博弈论和计算机模拟使用元胞自动机。通过这个模型，我们研究了赋予细胞运动性增加的突变可以通过由快速增殖的细胞组成的肿瘤扩散的情况。该分析提出了有助于防止良性肿瘤向恶性和侵袭性发展的治疗方法。
英文摘要：
Tumour cells have to acquire a number of capabilities if a neoplasm is to become a cancer. One of these key capabilities is increased motility which is needed for invasion of other tissues and metastasis. This paper presents a qualitative mathematical model based on game theory and computer simulations using cellular automata. With this model we study the circumstances under which mutations that confer increased motility to cells can spread through a tumour made of rapidly proliferating cells. The analysis suggests therapies that could help prevent the progression towards malignancy and invasiveness of benign tumours.
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