细胞外基质在记忆中的作用
The role of the extra cellular matrix on memory
摘要：
我们首先揭示了记忆的生物学模型，该模型一方面基于动作电位过程中轴突的机械振荡，另一方面基于当施加机械应变时细胞外基质成分的变化。由于这些变化，沿着最兴奋的神经元的细胞外基质的硬度将在靠近这些神经元处增加，胶原蛋白的弹塑性行为。这将创建链接到记忆效应的优先路径。在第二部分中，我们暴露了一个物理模型的基础上随机行走的动作电位的阵列组成的树突和轴突。最后一个模型表明，重复同一事件会导致对该事件的长时间记忆，而异相睡眠会导致不同事件的记忆。
英文摘要：
We expose first a biological model of memory based on one hand of the mechanical oscillations of axons during action potential and on the other hand on the changes in the extra cellular matrix composition when a mechanical strain is applied on it. Due to these changes, the stiffness of the extra cellular matrix along the most excited neurons will increase close to these neurons due to the growth of astrocytes around them and to the elastoplastic behavior of collagen. This will create preferential paths linked to a memory effect. In a second part, we expose a physical model based on random walk of the action potential on the array composed of dendrites and axons. This last model shows that repetition of the same event leads to long time memory of this event and that paradoxical sleep leads to the linking of different events put into memory.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
