将DNA序列分割成双态区和解链叉区
Segmentation of DNA sequences into twostate regions and melting fork regions
摘要：
通过计算工具准确预测和表征DNA解链结构域可以促进广泛的生物学应用。然而，直到现在还没有解链域预测的算法。主要的挑战包括数学映射的定量统计力学模型的定性描述的DNA解链域的困难，以及缺乏“金标准”和需要的一般性。本文介绍了一种新的方法来识别给定DNA序列上的双态区和熔解叉区。与我们以前的研究中使用的特设分割相比，新算法是基于边界概率分布，而不是标准的熔化图。我们证明了一个更详细的表征的DNA解链域地图可以使用我们的新方法，这种方法是独立的DNA解链模型的选择。我们希望这项工作能推动我们对DNA解链结构域的理解更进一步。
英文摘要：
The accurate prediction and characterization of DNA melting domains by computational tools could facilitate a broad range of biological applications. However, no algorithm for melting domain prediction has been available until now. The main challenges include the difficulty of mathematically mapping a qualitative description of DNA melting domains to quantitative statistical mechanics models, as well as the absence of 'gold standards' and a need for generality. In this paper, we introduce a new approach to identify the twostate regions and melting fork regions along a given DNA sequence. Compared with an ad hoc segmentation used in one of our previous studies, the new algorithm is based on boundary probability profiles, rather than standard melting maps. We demonstrate that a more detailed characterization of the DNA melting domain map can be obtained using our new method, and this approach is independent of the choice of DNA melting model. We expect this work to drive our understanding of DNA melting domains one step further.
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