arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 0804.0707cond-mat.softq-bio.SC
收藏

细胞碎片的粘性指状不稳定性

Viscous Fingering-like Instability of Cell Fragments

A. C. Callan-Jones, J. -F. Joanny, J. Prost

摘要:

我们提出了一种新的流动不稳定性,可能会出现在细胞骨架液的薄膜,如果与基板上的薄膜所在的摩擦是足够强的。我们考虑一个二维的,膜结合的片段包含肌动蛋白丝,从其最初的圆形状态,其中肌动蛋白聚合在边缘和径向向内流动,而解聚的片段被扰动。进行线性稳定性分析的初始状态,由于扰动的碎片边界,我们发现,在非常大的摩擦的限制,扰动肌动蛋白的速度和压力场服从非常相同的法律管辖的粘性指进不稳定性之间的界面不混溶流体在Hele-Shaw细胞。这种不稳定性的一个特点是显着的背景下,细胞运动,是它的存在是独立的强度之间的相互作用的细胞骨架丝和肌球蛋白马达,而且,它是完全驱动的自由能肌动蛋白聚合在片段边缘。

英文摘要:

We present a novel flow instability that can arise in thin films of cytoskeletal fluids if the friction with the substrate on which the film lies is sufficiently strong. We consider a two dimensional, membrane-bound fragment containing actin filaments that is perturbed from its initially circular state, where actin polymerizes at the edge and flows radially inward while depolymerizing in the fragment. Performing a linear stability analysis of the initial state due to perturbations of the fragment boundary, we find, in the limit of very large friction, that the perturbed actin velocity and pressure fields obey the very same laws governing the viscous fingering instability of an interface between immiscible fluids in a Hele-Shaw cell. A feature of this instability that is remarkable in the context of cell motility, is that its existence is independent of the strength of the interaction between cytoskeletal filaments and myosin motors, and moreover that it is completely driven by the free energy of actin polymerization at the fragment edge.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑