反馈失败是偏头痛和中风中去极化扩散的一种常见机制
Failure of feedback as a putative common mechanism of spreading depolarizations in migraine and stroke
摘要：
皮质功能的稳定性主要取决于适当的调节。在偏头痛和中风的情况下，跨膜化学梯度的破坏可以通过皮质组织传播。这种紧急的时空模式的一个伴随的组成部分是作为缓慢的电压变化检测到的细胞的去极化。~3 mm/min的速度表明扩散的贡献。我们提出了一种机制，扩展去极化（SD），依赖于一个非局部或非瞬时反馈的反应扩散系统。根据反馈的特征空间和时间尺度，皮层SD的传播可以通过转移分叉线来抑制，该分叉线将脉冲传播的参数区域与局部干扰消失的区域分开。这种反馈的优化阐述了不同的控制方案和控制参数的范围。
英文摘要：
The stability of cortical function depends critically on proper regulation. Under conditions of migraine and stroke a breakdown of transmembrane chemical gradients can spread through cortical tissue. A concomitant component of this emergent spatio-temporal pattern is a depolarization of cells detected as slow voltage variations. The velocity of ~3 mm/min indicates a contribution of diffusion. We propose a mechanism for spreading depolarizations (SD) that rests upon a nonlocal or non-instantaneous feedback in a reaction-diffusion system. Depending upon the characteristic space and time scales of the feedback, the propagation of cortical SD can be suppressed by shifting the bifurcation line, which separates the parameter regime of pulse propagation from the regime where a local disturbance dies out. The optimisation of this feedback is elaborated for different control schemes and ranges of control parameters.
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