NanoBiosensors的筛选有限应答
Screening-Limited Response of NanoBiosensors
摘要：
尽管纳米级生物传感器在基因组学和蛋白质组学应用中对生物分子的高灵敏度电子检测具有巨大的潜力，但实验观察到的传感器响应（S）的许多方面在动力学响应或电筛选的一致理论框架内是无法解释的。本文结合Poisson-Boltzmann方程和反应扩散方程的解析解，研究了纳米生物传感器的电响应随目标分子浓度、时间、盐浓度的变化规律，并与传感器表面的分形维数成反比。我们的分析提供了一个连贯的理论解释各种各样的令人费解的实验数据，迄今为止，无视直观的解释。
英文摘要：
Despite tremendous potential of highly sensitive electronic detection of bio-molecules by nanoscale biosensors for genomics and proteomic applications, many aspects of experimentally observed sensor response (S) are unexplained within consistent theoretical frameworks of kinetic response or electrical screening. In this paper, we combine analytic solutions of Poisson-Boltzmann and reaction-diffusion equations to show that the electrical response of nanobiosensor varies logarithmically with the concentration of target molecules, time, the salt concentration, and inversely with the fractal dimension of sensor surface. Our analysis provides a coherent theoretical interpretation of wide variety of puzzling experimental data that have so far defied intuitive explanation.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
