嗅觉传感器的嗅觉受体:大鼠I7和人17-40电反应的比较研究
Olfactory receptors for a smell sensor: A comparative study of the electrical responses of rat I7 and human 17-40
摘要:
在本文中,我们探讨了相关的电特性的嗅觉受体(ORs),一个从大鼠OR I7和其他从人类OR 17-40,这是感兴趣的嗅觉纳米生物传感器的实现。调查比较现有的实验,来自电化学阻抗谱,从阻抗网络蛋白质类似物,最近开发的理论预期。由于蛋白质的感测作用而引起的响应的变化与单个蛋白质所经历的构象变化相关。理论和实验之间的令人满意的协议点的一类新的纳米生物传感器的基础上的传感蛋白质的电特性的发展是有前途的。
英文摘要:
In this paper we explore relevant electrical properties of two olfactory receptors (ORs), one from rat OR I7 and the other from human OR 17-40, which are of interest for the realization of smell nanobiosensors. The investigation compares existing experiments, coming from electrochemical impedance spectroscopy, with the theoretical expectations obtained from an impedance network protein analogue, recently developed. The changes in the response due to the sensing action of the proteins are correlated with the conformational change undergone by the single protein. The satisfactory agreement between theory and experiments points to a promising development of a new class of nanobiosensors based on the electrical properties of sensing proteins.
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